The major focus of research in the Yarden lab is the study of molecular mechanisms involved in fungal growth and development. We are currently focusing on the study of cell wall biosynthesis and on involvement of protein phosphorylation in the regulation of hyphal elongation and branching. More recently, we have been studying fungi in their natural environment (including soil and in association with plants and sessile marine animals) and their interactions with other species. We are taking advantage of genetic and biochemical tools developed for such studies, in different fungi, in order to advance our knowledge of fungal biology. We hope that a better understanding of such processes, some of which are unique to fungi, may provide a basis for designing rational approaches to either affect fungal proliferation or enhance specific traits of fungi used in biotechnology.
71502 - Introduction to Plant Pathology course site
71514 - Selected Topics in Plant Pathology course site
71929 - Molecular Aspects of Fungal Biology and Plant Fungus Interactions course site
Gortikov, M., Yakubovich, E., Wang, Z., Lopez-Giraldez, F., Tu, Y., Townsend, J.P. and Yarden, O. 2022. Differential expression of cell wall remodeling genes is part of the dynamic phase-specific transcriptional program of conidial germination of Trichoderma asperelloides. J. Fungi 8(8):854. https://www.mdpi.com/2309-608X/8/8/854
Wang, Z., Lopez-Giraldez, F., Slot, J., Yarden, O., Trail, F., and Townsend, J.P. 2022. Secondary metabolism gene clusters exhibit increasingly dynamic and differential expression during asexual growth, conidiation, and sexual development in Neurospora crassa. mSystems 7: e00232-22. https://journals.asm.org/doi/10.1128/msystems.00232-22
Crous, P.W., Boers, J., Holdom, D., Osieck, E.R., Steinrucken, T.V., Tan, Y.P., Vitelli, J.S., Shivas, R.G., Barrett, M., Boxshall, A.-G., Broadbridge, J., Larsson, E., T. Lebel, T., Pinruan, U., Sommai, S., Alvarado, P., Bonito, G., Decock, C.A., De la Peña-Lastra, S., Delgado, G., Houbraken, J., Raja, H.A., Rigueiro-Rodríguez, A., Rodríguez, A., Wingfield, M.J., Adams, S.J., Akulov, A., AL-Hidmi, T., Antonín, V., Arauzo, S., Arenas, F., Armada, F., Aylward, J., Bellanger, J.-M., Berraf-Tebbal, A., Bidaud, A., Boccardo, F., Cabero, J., Calledda, F., G. Corriol, G., Crane, J.L., Dearnaley, J.D.W., Dima, B., Dovana, F., Eichmeier, A., Esteve-Raventós, F., Fine, M., Ganzert, L., García, D., Garcia, D.T., Gené, J., Gutiérrez, A., Iglesias, P., Istel, L., Izquierdo, A.M., Jangsantear, P., Jansen, G.M., Jeppson, M., Karun, N.C., Karich, A., Khamsuntorn, P., Kokkonen, K., Kolařík, M., Kubátová, A., Labuda, R., Lagashetti, A.C., Lifshitz, N., Linde, C., Loizides, M., Luangsa-ard, J.J., Lueangroenkit, P., Maciá-Vicente, J.G., Mahadevakumar, S., Mahamedi, A.E., Malloch, D.W., Marincowitz, S., Mateos, A., Moreau, P.-A., Miller, A.N., Molia, A., Morte, A., Navarro-Ródenas, A., Nebesářová, J., Nigrone, E., Nuthan, B.R., Oberlies, N.H., Pepori, A.L., Rämä, T., Rapley, D., Reschke, K., Robicheau, B.M., Roets, F., Roux, J., Saavedra, M., Sakolrak, B., Santini, A., Ševčíková, H., Singh, P.N., Singh, S.K., Somrithipol, S., Spetik, M., Sridhar, K.R., Starink-Willemse, M., Taylor, V.A., van Iperen, A.L., Vauras, J., Walker, A.K., Wingfield, B.D., Yarden, O. and Groenewald, J.Z. 2022. Fungal planet description sheets: 1383–1435. 1418 Microascus rothbergiorum. Persoonia 48: 261– 371. https://www.ingentaconnect.com/content/nhn/pimj/2022/00000048/00000001/art00008;jsessionid=22y1g1d4voryn.x-ic-live-01
Gortikov, M., Wang, Z., Steindorff, A.S., Grigoriev, I.V., Druzhinina, I.S., Townsend, J.P. and Yarden, O. 2022. Sequencing and analysis of the entire genome of the mycoparasitic bioeffector fungus Trichoderma asperelloides strain T 203 (Hypocreales). Microbiol. Resour. Announc. 11 :e00995-21. https://journals.asm.org/doi/full/10.1128/mra.00995-21?rfr_dat=cr_pub++0pubmed&url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org
Nomberg, G., Marinov, O., Karavani, E., Manasherova, E., Zelinger, E., Yarden, O. and Cohen, H. 2022. Cucumber fruit skin reticulation affects post-harvest traits. Postharvest Biology and Technology 194, 112071. https://www.sciencedirect.com/science/article/pii/S0925521422002393
Herold, I, Zolti, A., Garduno-Rosales, M., Wang, Z., Lopez-Giraldez, F., Murino-Perez, R.R., Townsend, J.P., Ulitsky, I. and Yarden, O. 2021. The GUL-1 protein binds multiple RNAs involved in cell wall remodeling and affects the MAK-1 pathway in Neurospora crassa. Front. Fungal Biol. 2:672696. https://www.frontiersin.org/articles/10.3389/ffunb.2021.672696/full
Ben Dor Cohen, E., Ilan, M. and Yarden, O. 2021. The culturable mycobiome of mesophotic Agelas oroides: constituents and changes following sponge transplantation to shallow water. J. Fungi 7(7): 567. https://www.mdpi.com/2309-608X/7/7/567
Lifshitz, N., Hazanov, L., Fine, M. and Yarden, O. 2020. Seasonal variations in the culturable mycobiome of Acropora loripes along a depth gradient. Microorganisms 8, 1139; https://doi.org/10.3390/microorganisms8081139.
Feldman, D., Yarden, O. and Hadar, Y. 2020. Seeking the roles for fungal small-secreted proteins in affecting saprophytic lifestyles. Front. Microbiol. 11:455 https://www.frontiersin.org/articles/10.3389/fmicb.2020.00455/full
Hou, L.W., Groenewald, J.Z., Pfenning, L.H., Yarden, O., Crous, P.W. and Cai, L. 2020. The phoma-like dilemma. Stud. Mycol. https://doi.org/10.1016/j.simyco.2020.05.001
Meyer, V., Evelina Y. Basenko, E.Y., Benz, JP, Braus, G.H., Caddick, M.X, Csukai, M., de Vries, R.P., Endy, D., Frisvad, J.C., Gunde-Cimerman, N., Haarmann, T., Hadar, Y., Hansen, K., Johnson, R.I., Keller, N.P., Kraševec, N., Mortensen, U.H., Perez, R., Ram, A.F.J., Record, E., Ross, P., Shapaval, V., Steiniger, C., van den Brink, H., van Munster, J., Yarden, O. and Wösten, H.A.B. 2020. Growing a circular economy with fungal biotechnology: A white paper. Fung. Biol. Biotech. 7, 5. https://fungalbiolbiotech.biomedcentral.com/articles/10.1186/s40694-020-00095-z
Alder-Rangel, A., Idnurm, A., Brand, A.C., Brown, A.J.P., Gorbushina, A.,Kelliher, C.M., Campos, C.B., Levin, D.E., Bell-Pedersen, D., Dadachova, E., Bauer, F.F., Gadd, G.M.,Braus, G.H., Braga, G.U.L., Brancini, G.T.P., Walker, G.M., Druzhinina, I., Pócsi, I., Dijksterhuis, J.,Aguirre, J., Hallsworth, J.E., Schumacher, J., Wong, K.H., Selbmann, L., Corrochano, L.M., Kupiec, M.,Momany, M., Molin, M., Requena, N., Yarden, O., Cordero, R.J.B., Fischer, R., Pascon, R.C., Mancinelli,R.L., Emri, T., Basso, T.O., Rangel, D.E.N. 2020. The Third International Symposium on Fungal Stress –ISFUS. Fung. Biol. 124: 235-252. https://www.sciencedirect.com/science/article/pii/S1878614620300271?via%3Dihub
Feldman, D., Kowbel, D.J., Cohen, A., Glass, N.L., Hadar, Y. and Yarden, O. 2019. Identification and manipulation of Neurospora crassa genes involved in sensitivity to furfural. Biotech. Biofuels 12:210. https://link.springer.com/article/10.1186/s13068-019-1550-4
Feldman, D., Amedi, N., Carmeli, S., Yarden, O. and Hadar, Y. 2019. Small secreted proteins (SSPs) act as a checkpoint for fungal development and metabolism in the white-rot fungus Pleurotus ostreatus. Appl. Environ. Microbiol. 85 (15): e00761-19. doi: 10.1128/AEM.00761-19.
Herold, I., Kowbel, D., Delgado-Álvarez, D., Garduño-Rosales, M., Mouriño-Pérez, R.R. and Yarden, O. 2019. Transcriptional profiling and localization of GUL-1, a COT-1 pathway component, in Neurospora crassa. Fung. Genet. Biol. 126:1-11 https://doi.org/10.1016/j.fgb.2019.01.010
Wang, Z., Miguel-Rojas, C., Lopez-Giraldez, F., Yarden, O., Trail, F. and Townsend, J. 2019. Metabolism and development during conidial germination in response to a carbon-nitrogen-rich synthetic or a natural source of nutrition in Neurospora crassa. mBio 10:e00192-19. https://doi.org/10.1128/mBio .00192-19
Amend, A., Burgaud, G., Cunliffe, M., Edgcomb, V.P., Ettinger, C., Gutiérrez, M.H., Heitman, J., Hom, E.F.Y., Ianiri, G., Jones, A.C., Kagami, M., Picard, K.T., Quandt, C.A., Raghukumar, S., Riquelme, M., Stajich, J., Vargas-Muñiz, J., Walker, A.K., Yarden, O. and Gladfelter, A.S. 2019. Fungi in the marine environment: open questions and unsolved problems. mBio 10:e01189-18. https://doi.org/10.1128/mBio.01189-18.
Aharoni-Kats, L., Zelinger, E., Chen, S. and Yarden, O. 2018 Altering Neurospora crassa MOB2A exposes its functions in development and affects its interaction with the NDR kinase COT1. Mol. Microbiol. 108: 641–660 (featured on the cover) https://doi.org/10.1111/mmi.13954
du Plessis, I.L., Druzhinina, I.S., Atanasova, L., Yarden, O. and Jacobs, K. 2018. The diversity of Trichoderma species from soil in South Africa with five new additions. Mycologia 110:559-583 (featured on the cover) https://www.tandfonline.com/doi/abs/10.1080/00275514.2018.1463059
Yoav, S., Salame, T.M., Feldman, D., Levinson, D., Ioelovich, M., Morag, E., Yarden, O., Bayer, E.S. and Hadar, Y. 2018. Effects of cre1 modification in the white-rot fungus Pleurotus ostreatus PC9: Altering substrate preference during biological pretreatment. Biotech. 11:212 https://doi.org/10.1186/s13068-018-1209-6
Shomin-Levi, H. and Yarden, O. 2017. The Neurospora crassa PP2A regulatory subunits RGB1 and B56 are required for proper growth and development and interact with the NDR kinase COT1. Front. Microbiol. 8:1694. doi: 10.3389/fmicb.2017.01694 https://www.frontiersin.org/articles/10.3389/fmicb.2017.01694/full
Herold, I. and Yarden, O. 2017. Regulation of Neurospora crassa cell wall remodeling via the cot-1 pathway is mediated by gul-1. Curr. Genet. 63:145-159.http://link.springer.com/article/10.1007/s00294-016-0625-z/fulltext.html#Abs1
Nimri, L., Spivak, O., Tal, D., Schälling, D., Peri, I., Graeve, L., Salame, T.M., Yarden, O., Hadar, Y. and Schwartz, B. 2017. A recombinant fungal compound induces anti-proliferative and pro-apoptotic effects on colon cancer cells. Oncotarget 8:28854-28864. http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path%5b%5d=15859&pubmed-linkout=1
Simkovitch, R., Gajst, O., Zelinger, E, Yarden, O. and Huppert, D. 2017. Irradiation by blue light in the presence of a photoacid confers changes to colony morphology of the plant pathogen Colletotrichum gloeosporioides. Photochem. Photobiol. B: Biol. 174:1-9. http://www.sciencedirect.com/science/journal/10111344/174?sdc=1
Feldman, D., Kowbel, D., Glass, N.L., Yarden, O. and Hadar, Y. 2017. A role for small secreted proteins (SSPs) in a saprophytic fungal lifestyle: Ligninolytic enzyme regulation in Pleurotus ostreatus. Sci. Rep. 7: 14553. https://www.nature.com/articles/s41598-017-15112-2
Yarden, O. 2016. Model fungi: engines of scientific insight. Fung. Biol. Rev. 30:33-35. http://www.sciencedirect.com/science/article/pii/S1749461316300264
Knop, D., Levinson, D., Makovitzki, A., Agami, A., Lere, E., Mimram, A., Yarden, O., and Hadar, Y. 2016. Limits of versatility of versatile peroxidase. Appl. Environ. Microbiol. 82:4070-4080. http://aem.asm.org/content/82/14/4070.abstract?sid=3cf26564-2dc1-408f-bd88-8afb429437fe
Lang-Yona, N., Shuster-Meiseles, T., Mazar, Y., Yarden, O. and Rudich, Y. 2016. Impact of urban air pollution on the allergenicity of Aspergillus fumigatus conidia: Field sampling supported by laboratory experiments. Sci. Total Environ. 541:365-371. http://www.sciencedirect.com/science/article/pii/S004896971530718X
López-Legentil, S., Erwin, P.M., Turon, M. and Yarden, O. 2015. Diversity of fungi isolated from three temperate ascidians. Symbiosis 66:99-106.http://link.springer.com/article/10.1007/s13199-015-0339-x
Cohen, R., Orgil, G., Burger, Y., Saar, U., Elkabetz, M., Tadmor, Y., Edelstien, M., Belausov, E., Maymon, M., Freeman, S. and Yarden, O. 2014. Differences in the responses of melon accessions to Fusarium crown rot and their colonization by Fusarium oxysporum f. sp. radicis cucumerinum. Plant Pathology 64:655-663http://onlinelibrary.wiley.com/doi/10.1111/ppa.12286/abstract
Knop, D., Yarden, O. and Hadar, Y. 2015. The ligninolytic peroxidases in the genus Pleurotus: Divergence in activities, expression and potential applications. Appl. Microbiol. Biotechnol. 99:1025-1038. http://link.springer.com/article/10.1007/s00253-014-6256-8
Kabbage, M., Yarden, O. and Dickman, M.B. 2015. Dining habits of Sclerotinia sclerotiorum: switching from biotrophic to necrotrophic lifestyle. Plant Sci. 233:53–60.http://www.sciencedirect.com/science/article/pii/S0168945214003057
Feldman, D., Kowbel, D.J., Glass, N.L., Yarden, O. and Hadar, Y. 2015. Detoxification of 5-hydroxymethylfurfural by the Pleurotus ostreatus lignolytic enzymes aryl alcohol oxidase and dehydrogenase. Biotech. Biofuels 8:63. http://www.biotechnologyforbiofuels.com/content/8/1/63
Yarden, O. 2014. Fungal association with sessile marine invertebrates. Front. Microbiol. 5:228 http://journal.frontiersin.org/Journal/10.3389/fmicb.2014.00228/abstract
Koch, L., Lodin, A., Herold, I., Ilan, M. Carmeli, S. and Yarden, O. 2014. Sensitivity of Neurospora crassa to a marine-derived Aspergillus tubingensis anhydride exhibiting antifungal activity that is mediated by the MAS1 protein. Mar. Drugs 12:4713-4731 http://www.mdpi.com/1660-3397/12/9/4713
Yarden, O., Veluchamy, S., Dickman, M.B. and Kabbage, M. 2014. Sclerotinia sclerotiorum catalase SCAT1 increases tolerance to oxidative stress, regulates ergosterol levels and controls pathogenic development. Physiol. Mol. Plant Pathol. 85:34-41 http://www.sciencedirect.com/science/article/pii/S0885576513000763
Salame, T.M., Knop, D., Levinson, D., Mabjeesh, S.J., Yarden, O. and Hadar, Y. 2014. Inactivation of a Pleurotus ostreatus versatile-peroxidase-encoding gene (mnp2) results in reduced lignin degradation. Environ. Microbiol. 16: 265–277 http://onlinelibrary.wiley.com/doi/10.1111/1462-2920.12279/abstract (featured on the cover)
Knop, D., Ben-Ari, J., Salame, T.M., Levinson, D., Yarden, O. and Hadar, Y. 2014. Mn2+-deficiency reveals a key role for the Pleurotus ostreatus versatile MnP (VP4) in oxidation of aromatic compounds. Appl. Microbiol. Biotechnol. 98:6795–6804.
Ziv, C., Feldman, D., Aharoni-Kats, L., Chen, S., Liu, Y. and Yarden, O. 2013. The N-terminal region of the Neurospora NDR kinase COT1 regulates morphology via its interactions with MOB2A/B. Mol. Microbiol. 90:383-399 http://onlinelibrary.wiley.com/doi/10.1111/mmi.12371/abstract (featured on the cover).
Feldman, D., Ziv, C., Gorovits, R., Efrat, M. and Yarden, O. 2013. Neurospora crassa protein arginine methyl transferases are involved in growth and development and interact with the NDR kinase COT1. PLoS One http://www.plosone.org/article/info%3Adoi%2F10.1371%2Fjournal.pone. 0080756#abstract0"
Lang-Yona, N., Levin, Y., Dannemiller, K., Yarden, O., Peccia, J. and Rudich, Y. 2013. Changes in atmospheric CO2 influence the allergenicity of Aspergillus fumigatus. Glob. Chang. Biol. 19: 2381–2388. http://onlinelibrary.wiley.com/doi/10.1111/gcb.12219/abstract
Salame, T.M., Knop, D., Levinson, D., Yarden, O. and Hadar, Y. 2013. Redundancy amongst manganese-peroxidases in Pleurotus ostreatus. Appl. Environ. Microbiol. 79: 2405–2415 http://aem.asm.org/content/79/7/2405.abstract?sid=4ff9868a-69c2-414a- a200-647ab2cd2a1e (featured on the cover).
Panizel, I., Yarden, O., Ilan, M and Carmeli, S. 2013. Eight novel peptaibols from sponge-associated Trichoderma atroviride. Mar. Drugs 11:4937-4960.http://www.mdpi.com/1660-3397/11/12/4937
Salame, T., Knop, D., Tal, D., Levinson, D., Yarden, O. and Hadar, Y. 2012. A gene-targeting system for Pleurotus ostreatus: Demonstrating the predominance of versatile-peroxidase (mnp4) by gene replacement. Appl. Environ. Microbiol. 78: 5341-5352 (featured on the cover)
Salame, T., Knop, D., Tal, D., Levinson, D., Mabjeesh, S.J., Yarden, O. and Hadar, Y. 2012. Release of Pleurotus ostreatus versatile-peroxidase from Mn2+ repression enhances anthropogenic and natural substrate degradation. PLoS ONE 7(12): e52446. doi:10.1371/journal.pone.0052446.
Ferandez-Fueyo, E., Ruiz-Duenas, F., Ferreira, P., Floudas, D., Hibbett, D., Canessa, P., Larrondo, L., James, T., Seelenfreund, D., Lobos, S., Polanco, R., Tello, M., Honda, Y., Watanabe, T., Jae San, R., Kubicek, C., Schmoll, M., Gaskell, J., Hammel, K., St. John, F., Vanden Wymelenberg, A., Sabat, G., Splinter BonDurant, S., Syed, K., Yadav, J., Doddapaneni, H., Subramanian, V., Laven, J., Oguiza, J., Perez, G., Pisabarro, A., Ramirez, L., Santoyo, F., Master, E., Coutinho, P., Henrissat, B., Lombard, V., Magnuson, J., Kues, U., Hori, C., Igarashi, K., Samejima, M., Held, B., Barry, K., LaButti, K., Lapidus, A., Lindquist, E., Lucas, S., Riley, R., Salamov, A., Hoffmeister, D., Schwenk, D., Hadar, Y., Yarden, O., de Vries, R., Wiebenga, A., Stenlid, J., Eastwood, D., Grigoriev, I., Berka, R., Blanchette, R., Kersten, P., Martinez, A., Vicuna, R., and Cullen, D. 2012.Comparative genomics of Ceriporiopsis subvermispora and Phanerochaete chrysosporium provide insight into selective ligninolysis. Proc. Natl. Acad. Sci. USA. 109:5458-5463.
Lang-Yona, N., Dannemiller, K., Yamamoto, N., Peccia, J., Yarden, O., Burshtein, N. and Rudich, Y. 2012. Annual distribution of allergenic fungal spores in atmospheric particulate matter in the eastern Mediterranean; A comparative study between ergosterol and quantitative PCR analysis. Atmos. Chem. Phys. 12:2681-2690.
Kapri-Pardes, E., Haviv, H., Mahmoud, Y., Ilan, M., Khalfin-Penigel, I., Carmeli, S., Yarden, O. and Karlish, S.J.D. 2011. Stabilization of the α2 isoform of Na,K-ATPase by mutations in a phospholipid binding pocket. J. Biol. Chem. 286:42888-42899 abstract
Bardea, A., Burshtein, N., Rudich, Y., Salame, T., Ziv, C., Yarden, O. and Naaman, R. Sensitive detection and identification of DNA and RNA using a patterned capillary tube (PCT). Anal. Chem. 83:9418-9423 abstract
Amselem, J., Cuomo, C.A. , van Kan, J.A.L., Viaud, M., Benito, E.P., Couloux, A., Coutinho, P.M., de Vries, R.P., Dyer, P.S., Fillinger, S., Fournier, E., Gout, L., Hahn, M., Kohn, L., Lapalu, N., Plummer, K.M., Pradier, J.-M., Quévillon, E., Sharon, A., Simon, A., ten Have, A., Tudzynski, B., Tudzynski, P., Wincker, P., Andrew, M., Anthouard, V., Beffa, R., Benoit, I., Bouzid, O., Chen, Z., Choquer, M., Collémare, J., Cotton, P., Danchin, E.G., Da Silva, C., Gautier, A., Giraud, C., Giraud, T., Gonzalez, C., Grossetete, S., Güldener, U., Henrissat, B., Howlett, B., Kodira, C., Kretschmer, M., Lappartient, A., Leroch, M., Levis, C., Mauceli, E., Neuvéglise, C., Oeser, B., Pearson, M., Poulain, J., Poussereau, N., Quesneville, H., Rascle, C., Schumacher, J., Ségurens, B., Sexton, A., Silva, E., Sirven, C., Soanes, D.M., Talbot, N.J., Yandava, C., Yarden, O., Zeng, Q., Rollins, J.A., Lebrun, M.-H., Dickman, M.B. 2011. Genomic analysis of the necrotrophic fungal pathogens Sclerotinia sclerotiorum and Botrytis cinerea. PLOS Genetics 7: e1002230. doi:10.1371/journal.pgen.1002230.
Denisov, Y. Yarden, O. and Freeman, S. 2011. The transcription factor SNT2 is involved in fungal respiration and reactive oxidative stress in Fusarium oxysporum and Neurospora crassa. Physiol. Mol. Plant Pathol. 2011: 76: 137-143
Gal-Hemed, I., Atanasova, L., Komon-Zelazowska, M., Druzhinina, I.S., Viterbo, A. and Yarden, O. 2011. Marine isolates of Trichoderma as potential halotolerant agents of biological control for arid-zone agriculture. Appl. Environ. Microbiol. 77:5100-5109 abstract
Cohen, E., Koch, L., Myint Thu, K., Rahamim, Y., Aluma, Y., Ilan, M., Yarden, O. and Carmeli, S. 2011. Novel terpenoids of the fungus Aspergillus insuetus isolated from the Mediterranean sponge Psammocinia sp. collected along the coast of Israel. Bioorg. Med. Chem. 19:6587-6593 doi:10.1016/j.bmc.2011.05.0450
Costantino, V., Mangoni, A., Teta, R., Kra-Oz, G. and Yarden, O. 2011. Neurosporaside, a tetraglycosylated sphingolipid from Neurospora crassa. J. Nat. Prod. 74:554-558
Riquelme, M., Yarden, O., Bartinicki-Garcia, S., Bowman, B., Castro-Longoria, E., Free, S., Felissner, A., Freitag, M., Lew, R.R., Mourino-Perez, R., Plamann, M., Rasmussen, C., Richthammerj, C., Roberson, R.W., Sanchez-Leon, E., Seiler, S. and Waters, M.K., 2011. Architecture and development of the Neurospora crassa hypha - a model cell for polarized growth. Fung. Biol.115:446-474 doi:10.1016/j.funbio.2011.02.008
Salame, T.M., Ziv, C., Hadar, Y. and Yarden, O. 2011. RNAi as a potential tool for biotechnological applications. Appl. Microbiol. Biotech. 89:501-512 abstract.
Denisov, Y., Freeman, S. and Yarden, O. 2011. Inactivation of Snt2, a BAH/PHD-containing transcription factor, impairs pathogenicity and increases autophagosome abundance in Fusarium oxysporum. Mol. Plant Pathol. 12:449-461 abstract
Osherov, N. and Yarden, O. 2010. The fungal cell wall. Pages 224-237 in: Borkovich, K.A. and Ebbole, D.J. (eds). Cellular and Molecular Biology of Filamentous Fungi. American Society of Microbiology Press.
Ziv, C. and Yarden, O. 2010. Gene silencing for functional analysis: Assessing RNAi as a tool for manipulation of gene expression. Pages 77-100 in: Sharon, A. (ed) Molecular Biology Methods for Fungi. Humana Press.
Paz, Z., Komon-Zelazowska, M., Druzhinina, I.S., Aveskamp, M.M., Schnaiderman, A. Aluma, A., Carmeli, S., Ilan, M. and Yarden, O. 2010. Diversity and potential antifungal properties of fungi associated with a Mediterranean sponge. Fung. Divers. 42:17-26 article
Dvash, E. Kra-Oz, G. Ziv, C. Carmeli, S. and Yarden, O. 2010. The NDR kinase DBF-2 is involved in regulation of mitosis, conidial development and glycogen metabolism in Neurospora crassa. Eukaryot. Cell 9:502-513 pubmed
Salame, T.H., Yarden, O. and Hadar, Y. 2010. Pleurotus ostreatus manganese-dependent peroxidase silencing impairs decolorization of Orange II. Microb. Biotech. 3:93-106. abstract
Ziv, C., Kra-Oz, G., Gorovits, R., Maerz, S., Seiler, S. and Yarden, O. 2009. Cell elongation and branching are regulated by differential phosphorylation states of the NDR kinase COT1 in Neurospora crassa. Mol. Microbiol. 74:974-989 pubmed
Maerz, S. Dettmann, A., Ziv, C., Liu, Y., Valerius, O., Yarden, O. and Seiler, S. 2009. MOB1-DBF2 and MOB2A/2B-COT1 function as distinct modules during septation and tip growth in Neurospora crassa. Mol. Microbiol. 74:707-723. pubmed
Gellerman, G., Pariente, N., Paz, Z., Shnaiderman, A and Yarden, O. 2009. Synthesis and antifungal activity of -trifluroalkyl aminovinylketone derivatives. J. Agric. Fd. Chem. 57:8303-8307. pubmed
Ein-Gil, N., Ilan, M., Carmeli, S., Smith, G.W. Pawlik, J.R. and Yarden, O. 2009. Presence of Aspergillus sydowii, a pathogen of gorgonian sea-fans in the marine sponge Spongia obscura ISME J. 3:752-755. pubmed
Aly, R., Cholakh, H., Joel, D.M., Leibman, D., Steinitz, B., Zelcer, A., Naglis, A., Yarden, O. and Gal-On, A.. 2009 Gene silencing of mannose 6-phosphate reductase in the parasitic weed Orobanche aegyptiaca through the production of homologous dsRNA sequences in the host. Plant Biotech. J. 7:487-498. pubmed
Levy, M., Erental, A. and Yarden, O. 2008. Efficient gene replacement and direct hyphal transformation in Sclerotinia sclerotiorum. Mol. Plant Pathol. 9:719-725. pubmed
Maerz, S., Ziv, C., Vogt, N., Helmstaedt, K., Cohen, N., Gorovits, R., Yarden, O. and Seiler, S. 2008. The Ndr kinase COT1, and the MAP kinases MAK1 and MAK2 genetically interact to regulate filamentous growth, hyphal fusion and sexual development in Neurospora crassa. Genetics 179:1313-1325. pubmed
Resheat-Eini, Z., Zelter, A., Gorovits, R., Read, N.D. and Yarden, O. 2008. The Neurospora crassa colonial temperature sensitive 2, 4 and 5 (cot-2, cot-4 and cot-5) genes encode regulatory and structural proteins required for hyphal elongation and branching. Fungal Genet. Rep. 55:32-36. web
Erental, A., Dickman, M. and Yarden, O. 2008. Sclerotial development in Sclerotinia sclerotiorum: Awakening molecular analysis of a "dormant" structure. Fung. Biol. Rev. 22:6-16.
Horowitz Brown, S., Yarden, O., Gollop, N., Chen, S., Zveibil, A., Belausov, E. Freeman, S. 2008. Differential protein expression in Colletotrichum acutatum: changes associated with reactive oxygen species (ROS) and nitrogen starvation implicated in pathogenicity on strawberry. Mol. Plant Pathol. 9:171-190.
Ziv, C., Gorovits, R. and Yarden, O. 2008. Carbon Source affects PKA-dependent polarity of Neurospora crassa in a CRE-1-dependent and independent manner. Fung. Genet. Biol. 45:103-116. pdf
Lotan-Pompan, M., Cohen, R. Yarden, O. Portnoy, V., Burger, Y. and Katzir, N. 2007. Trifluralin herbicide-induced resistance of melon to Fusarium wilt involves expression of stress- and defense-related genes. Mol. Plant Pathol. 8:9-22. pdf
Yarden, O. 2007. Model systems for studying the biology of filamentous fungi - rumors of their death should be postponed. Phytoparasitica 35:111-115. pdf
Yarden, O., Ainsworth, T.D., Roff, G., Leggat, W., Fine, M. and Hoegh-Guldberg, O. 2007. Increased prevalence of ubiquitous ascomycetes in an acropoid coral (Acropora formosa) exhibiting symptoms of brown band syndrome and skeletal eroding band. Appl. Environ. Microbiol. 73:2755-2757. pdf
Erental, A., Harel, A. and Yarden, O. 2007. Type 2A phosphoprotein phosphatase is required for asexual development and pathogenesis of Sclerotinia sclerotiorum. Mol. Plant-Microbe Interact. 20:944-954. pdf
Gerlitz, G., Livnat, I., Ziv, C., Yarden, O., Bustin, M. and Reiner, O. 2007. Migration cues induce chromatin alterations. Traffic 8:1521-1529. pdf
Harel, A., Bercovich,S. and Yarden, O. 2006. Calcineurin is required for sclerotial development and pathogenicity of Sclerotinia sclerotiorum in an oxalic acid-independent manner. Mol. Plant-Microbe Interact. 19:682-693. pdf
Horowitz, S., Freeman, S., Zveibil,A. and Yarden, O. 2006. A defect in nir1, a nirA-like transcription factor, confers morphological abnormalities and loss of pathogenicity in Colletotrichum acutatum. Mol. Plant Pathol. 7:341-354. pdf
Divon H.H., Ziv C., Davydov O., Yarden O. and Fluhr R. 2006. The global nitrogen regulator, FNR1, regulates fungal nutrition-genes and fitness during Fusarium oxysporum pathogenesis. Mol. Plant Pathol.7:485-497. pdf
Seiler,S., Vogt, N., Ziv, C., Gorovits,R., and Yarden, O. 2006. The STE20/germinal center kinase POD6 interacts with the NDR kinaseCOT1 and is involved in polar tip extension in a motor protein-dependent mannerin Neurospora crassa. Mol. Biol. Cell 17:4070-4082. pdf
Reuveni, E., Leshkowitz, D. and Yarden, O. 2005. BioCloneDB: a database application to manage DNA sequence and gene expression data. Appl. Bioinformat. 4:277-280.
Harel, A., Gorovits, R. and Yarden, O. 2005. Changes in protein kinase A activity accompany sclerotial development in Sclerotinia sclerotiorum. Phytopathology 95:397-404. pdf
Denisov, D., Yarden, O. and Freeman, S. 2005. Impaired purine biosythesis affects pathogenicity of Fusarium oxysporum f. sp. melonis. Eur. J. Plant Pathol. 112:293-297.pdf
Gesner, S., Cohen, N., Ilan, M., Yarden, O. and Carmeli, S. 2005. Pandangolide 1a, a new metabolite of the sponge-associated fungus Cladosporium sp. and the absolute stereochemistry of Pandangolide 1 and iso-Cladospolide B. J. Nat. Prod. 68:1350-1353. pdf
Kerem, Z., German-Shashoua, H. and Yarden, O. 2004. Microwave-assisted extraction of bioactive saponins from chickpea (Cicer arietinum L.). J. Sci Food Agri. 85:406-412. pdf
Scheffer, J., Ziv, C., Yarden, O. and Tudzynski, P. 2004. The COT1 homologue CPCOT1 regulates polar growth and branching and is essential for pathogenicity in Claviceps purpurea. Fung. Genet. Biol. 42:107-118. pdf
Yarden, O. 2004. Cell Biology of Hyphae. pages 1-8 in: Arora, D.K (ed.) Handbook of Fungal Biotechnology. Marcel Dekker, New York.
Borkovich, K.A., Alex, L.A., Yarden, O., Freitag, M., Turner, G.E., Read, N.D., Seiler, S., Bell-Pedersen, D., Paietta, J., Plesofsky, N., Plamann, M., Goodrich-Tanrikulu, M. Schulte, U., Mannhaupt, G., Nargang, F.E., Radford, A., Selitrennikoff, C., Galagan, J.E., Dunlap, J.C., Loros, J.J., Catcheside, D., Inoue, H., Aramayo, R., Polymenis, M., Selker, E.U., Sachs, M.S., Marzluf, G.A., Paulsen, I., Davis, R., Ebbole, D.J., Zelter, A., Kalkman, E., ORourke, R., Bowring, F., Yeadon, J., Ishii, C., Suzuki, K., Sakai, W. and Pratt, R. 2004. Lessons from the genome sequence of Neurospora crassa: Tracing the path from genomic blueprint to multicellular organism. Microbiol. Molec. Biol. Rev. 68:1-108. abstract
Chen, C., Harel, A., Gorovits, R., Yarden, O. and Dickman, M. 2004. MAPK regulation of sclerotial development in Sclerotinia sclerotiorum is linked with pH and cAMP sensing. Mol. Plant-Microbe Interact. 17:404-413. abstract
Alkan, N., Gadkar, V., Coburn, J., Yarden, O. and Kapulnik, Y. 2004. Quantification of the AM fungus Glomus intraradices in host tissue using real-time PCR. New Phytol. 161:877-885. abstract
Yang, Y., He, Q., Cheng, P., Wrage, P., Yarden, O. and Liu, Y. 2004. Distinct roles for PP1 and PP2A in the Neurospora circadian clock. Genes Develop. 18:255-260. abstract
Horowitz, S., Yarden, O. Zveibil, A. and Freeman, S. 2004. Development of a robust screening method for pathogenicity of Colletotrichum species on strawberry seedlings enabling forward genetic studies. Plant Dis. 88:845-851. pdf
Nir-Paz, R., Strahilevitz, J., Shapiro, M., Keller, N., Goldschmied-Reouven, A., Yarden, O., Block, C and Polacheck, I. 2004. Clinical and epidemiological aspects of infections caused by Fusarium species: a collaborative study from Israel. J. Clin. Microbiol. 42:3456-3461. abstract
Zelter, A, Bencina, M., Bowman, B.W., Yarden, O. and Read, N.D. 2004. A comparative genomic analysis of the calcium signaling machinery in Neurospora crassa, Magnaporthe grisea, Aspergillus fumigatus and Saccharomyces cerevisiae. Fung. Genet. Biol. 41:827-841. abstract
Galagan, J., Calvo, S., Borkovich, K., Selker, E., Read, N.D., FitzHugh,W., Ma, L.-J., Smirnov, S., Purcell, S., Rehman, B., Elkins, T., Engels, R., Wang. S., Nielsen, C.B., Butler, J., Jaffe, D., Endrizzi, M., Qui, D., PIanakiev, P., Bell-Pedersen, D., Nelson, M.A., Werner-Washburne, M., Selitrennikoff, C.P., Kinsey, J.A., Braun, E.L., Zelter, A., Schulte, U., Kothe, G.O., Jedd, G., Mewes. W., Staben, C., Marcotte, E., Greenberg, D., Roy, A., Foley, K., Naylor, J., Stange-Thomann, N., Barrett, R., Gnerre, S., Kamal, M., Kamvysselis, M., Bielke, C., Rudd, S., Frishman, D., Krystofova, S., Rasmussen, C., Metzenberg, R.L., Perkins, D.D., Kroken, S., Catcheside, D., Li, W., Pratt, R.J., Osmani, S.A., DeSouza, C.P.C., Glass, L., Orbach, M.J., Berglund, J.A., Voelker, R., Yarden, O., Plamann, M., Seiler, S., Dunlap, J., Radford, A., Aramayo, R., Natvig, D.O., Alex, L.A., Mannhaupt, G., Ebbole, D.J., Freitag, M., Paulsen, I., Sachs, M.S, Lander, E.S, Nusbaum, C., Birren, B. (2003). The genome sequence of the filamentous fungus Neurospora crassa. Nature 422: 859-868. abstract
Zeke, T., Szr, B., K¢kai, E., Yatzkan, E., Yarden, O., Szir k, K., Fehr, Z., Gergely, P. and Dombr di, V. 2003. Expression of protein phosphatase 1 during the asexual development of Neurospora crassa. Comp. Biochem. Physiol. 134:161-170. abstract
Gorovits, R. and Yarden, O. 2003. Environmental suppression of Neurospora crassa cot-1 hyperbranching: a link between COT1 kinase and stress-sensing. Eukaryot. Cell 2:699-707. abstract
Yarden, O., Ebbole, D.J., Freeman, S., Rodriguez, R.J. and Dickman, M.B. 2003. Fungal Biology and Agriculture: Revisiting the Field. Mol. Plant-Microbe Interact. 16:859-866. abstract
Cohen, R., Persky, L., Hazan-Eitan, Z., Yarden, O. and Hadar, Y. 2002.Mn2+ alters peroxidase profiles and lignin degradation by the white-rot fungus Pleurotus ostreatusunder different nutritional and growth conditions. Appl. Biochem. Biotech. 102:415-429 abstract
Cohen, R., Yarden, O. and Hadar, Y. 2002. Lignocellulose affects Mn2+ regulation of peroxidase transcript levels in solid state cultures of Pleurotus ostreatus. Appl. Environ. Microbiol. 68:3156-3158. abstract
Yarden, A. and Yarden, O. 2002. Cooperative class preparation of a problem awareness file promotes meaningful learning among undergraduate students. J. Coll. Sci. Teach. 32:114-119.
Propheta, O., Vierula, J., Toporowski, P., Gorovits, R. and Yarden, O. 2001. The Neurospora crassa colonial temperature-sensitive 3 (cot-3) gene encodes protein elongation factor 2. Mol. Gen. Genet. 6:894-901. abstract
Lavid, N., Schwartz, A., Yarden, O. and Tel-Or, E. 2001. The involvement of ployphenols and peroxidase activities in heavy-metal accumulation by epidermal glands of the waterlily (Nymphaeaceae). Planta 212:323-331. abstract
Cohen, R., Hadar, Y. and Yarden, O. 2001. Transcript and activity levels of different Pleurotus ostreatus peroxidases are differentially affected by Mn2+. Environ. Microbiol. 3:312-322. abstract
Bakshi, S., Sztejnberg, A. and Yarden, O. 2001. Characterization of a cold-tolerant strain of Fusarium proliferatum, a biocontrol agent of grape downy mildew.Phytopathology 91:1062-1068.
Beth-Din, A. and Yarden, O. 2000. The Neurospora crassa chs-3 gene encodes an essential class I chitin synthase. Mycologia 92:6573.
Gorovits, R., Sjollema, K.A., Sietsma, J.H. and Yarden, O. 2000. Cellular distribution of COT1 kinase in Neurospora crassa. Fung. Genet. Biol. 30:63-70. abstract
Yatzkan, E. and Yarden O. 1999. The B regulatory subunit of protein phosphatase 2A is involved in different developmental stages in Neurospora crassa. Mol. Microbiol. 31:197-210. abstract
Yatzkan, E., Dombradi, V. and Yarden, O. 1999. Detection of a protein phosphatase 2A holoenzyme in Neurospora crassa. Fung. Genet. Newslt. 46:32-33. Rotem, Y., Yarden, O. and Sztejnberg, A. 1999. The mycoparasite Ampelomyces quisqualis expresses exgA, encoding an exo-b-1,3 glucanase, in culture and during mycoparasitism.Phytopathology 89:631-638.
Gorovits, R., Propheta, O., Kolot, M., Dombradi, V., and Yarden, O. 1999. A mutation within the catalytic domain of COT1 kinase confers changes in the presence of two COT1 isoforms and in Ser/Thr protein kinase and phosphatase activities in Neurospora crassa. Fung. Genet. Biol. 27:264-274. abstract
McDonald, B.A., Zhan, J., Yarden, O., Hogan, K., Garton, J. and Pettway, R.E. 1999. The population genetics of Mycosphaerella graminicola (anamorph Septoria tritici) and Phaeosphaeria nodorum (anamorph Stagonospora nodorum). pp 44-69 In: Lucas, J.A, Bowyer, P. and Anderson, H.M. (eds.) Septoria on Cereals: A Study of Pathosystems. CAB International, Wallingford United Kingdom.
Yarden, O. and Russo, V.E.A. 1999. Genetic and environmental influence on development of the filamentous fungus Neurospora crassa. pp 67-82 In: Russo, V.E.A., Cove, D., Edgar, L., Jaenisch, R. and Salamini, F. (eds.). Development-Genetics, Epigenetics and Environmental Regulation. Springer-Verlag, Berlin.
Dickman, M.B. and Yarden, O. 1999. Ser/Thr kinases and phosphatases in filamentous fungi. Fungal Genet. Biol. 26:99-117. abstract
Gamliel, A. and Yarden, O. 1998. Diversification of diseases affecting herb crops in Israel accompanies the increase in herb crop production. Phytoparasitica 26:53-58.pdf
Lauter, F.-R., Marchfelder, U., Russo, V.E.A., Yamashiro, C.T., Yatzkan, E. and Yarden, O. 1998. Photoregulation of cot-1, a kinase-encoding gene involved in hyphal growth in Neurospora crassa. Fung. Genet. Biol. 23:300-310. abstract
Yatzkan, E., Szoor, B., Feher, Z., Dombradi, V. and Yarden, O. 1998. Protein phosphatase 2A is involved in hyphal growth of Neurospora crassa. Mol. Gen Genet. 259:523-531. abstract
Szoor, B., Feher, Z., Zeke, Y., Gergely, P., Yarden, O., and Dombradi, Z. 1998. pzl-1 encodes a novel protein phosphatase-Z-like Ser/Thr phosphatase in Neurospora crassa.Biochim. Biophys. Acta 1388:260-266. abstract
Prokisch, H., Yarden, O., Mischler, M., Tropschug, M. and Barthelmess, I.B. 1997. Impairment of calcineurin function in Neurospora crassa reveals its essential role for hyphal growth, morphology and maintenance of the apical Ca2+-gradient. Mol. Gen. Genet. 256:104-114. abstract
Yatzkan, E. and Yarden, O. 1997. ppt-1, a Neurospora crassa PPT/PP5 subfamily serine/threonine protein phosphatase. Biochim. Biophys. Acta 1353:18-22 abstract
Weiss, N. Sztejnberg, A. and Yarden, O. 1996. The chsA gene, encoding a class I chitin synthase from Ampelomyces quisqualis. Gene 168:99-102. abstract
Yarden, O. and Russo, V.E.A. 1996. Changes in chitin deposition accompany runner hyphae branching of Gaeumannomyces graminis in culture. Mycol. Res. 100:444-448.
Beth Din, A., Specht, C.A., Robbins, P.W. and Yarden, O. 1996. chs-4, a class IV chitin synthase from Neurospora crassa. Mol. Gen. Genet. 250:214-222. abstract
Ostersetzer, O., Tabak, S., Yarden, O., Shapira, R. and Adam, Z. 1996. Immunological detection of homologs to bacterial proteases in higher plant chloroplasts. Eur. J. Biochem. 236:932-936. abstract
Cohen, R., Katzir, N., Schreiber, S., Greenberg, R. and Yarden, O. 1996. Occurrence of Sphaerotheca fuliginea race 3 on cucurbits in Israel. Plant Dis. 80:344.
Sietsma, J.H., Beth Din, A., Ziv, V., Sjollema, K.A. and Yarden, O. 1996. Membranous vesicles (chitosomes) are involved in chitin synthase compartmentalization and trafficking in Neurospora crassa. Microbiology 142:1591-1596. abstract
Buhr, T.L., Oved, S., Truesdell, G.M., Huang, C., Yarden, O. and Dickman, M.B. 1996. TB3, a glutamine-rich kinase-encoding gene from Colletotrichum trifoliicomplements the cot-1 mutant of Neurospora crassa. Mol. Gen. Genet. 251:565-572. abstract
Yatzkan, E. and Yarden, O. 1995. Inactivation of a single type 2A phosphoprotein phosphatase is lethal in Neurospora crassa. Curr. Genet. 28:458-466. abstract
Beth Din, A. and Yarden, O. 1994. The Neurospora crassa chs-2 gene encodes a non-essential chitin synthase. Microbiology 140:2189-2197.
abstract
Yarden, O. and Katan, T. 1993. Mutations leading to substitutions at amino acids 198 and 200 of beta tubulin that correlate with benomyl-resistance phenotypes of field strains of Botrytis cinerea. Phytopathology 83:1478-1483.
Yarden, O., Plamann, M.D., Ebbole, D.J. and Yanofsky, C. 1992. cot-1, a gene of Neurospora crassa required for hyphal elongation, encodes a protein kinase. EMBO J. 11:2159-2166. abstract
Yarden, O. and Yanofsky, C. 1991. Chitin synthase 1 plays a major role in cell wall biogenesis in Neurospora crassa. Genes and Develop. 5:2420-2430. abstract
Chunoti Changwal, PhD (in collaboration with the Hadar lab)
“The roles of small secreted proteins in the interactions between white rot and brown rot fungi”
Anne Yenewodage
" RNA-binding proteins and conidiation in Neurospora crassa”
Gladys Karungari (in collaboration with the Ziv lab, ARO)
“The molecular bases for Botrytis cinerea cold tolerance”
Liza Yakubovich
"Carbohydrate metabolism during germination of Trichoderma asperelloides"
Dor Marcus
Role of SSPs in Pleurotus ostreatus” (in collaboration with the Hadar lab, HUJI).
Lior Granit
“Genetic and physiological analyses of the coral-derived fungus Cladosporium halotolerans” (in collaboration with the Fine lab, HUJI)
Rotem Levi
“Fungal abundance and activity in the coral Stylophora pistillata”
Gal Nomberg
“Cucurbitaceous fruit skin reticulation as a defensive barrier against the gray mold fungus Botrytis cinerea” (in collaboration with the Cohen lab, ARO)
Danielle Reznik
Liraz Ron
Dan Weinberg (Amirim Honors Project)
Former students from the Yarden lab have found positions in academia and research institutes (e.g., Israel Institute for Biological Research, The Hebrew Univ., Tel-Aviv Univ., EMBL) in BioTech and MedTech industries (e.g., Novartis, Hazera Genetics, Sigma Chem. Co., XTLbio etc.) and at the Ministry of Health. The following is a list of former students from the Yarden lab:
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