The major focus of research in the Yarden lab is the study of molecular mechanisms involved in fungal growth and development. We are currently focusing on the study of cell wall biosynthesis and on involvement of protein phosphorylation in the regulation of hyphal elongation and branching. More recently, we have been studying fungi in their natural environment (including soil and in association with plants and sessile marine animals) and their interactions with other species. We are taking advantage of genetic and biochemical tools developed for such studies, in different fungi, in order to advance our knowledge of fungal biology. We hope that a better understanding of such processes, some of which are unique to fungi, may provide a basis for designing rational approaches to either affect fungal proliferation or enhance specific traits of fungi used in biotechnology.
cot-1, a mutant of the filamentous fungus Neurospora crassa, which at higher temperatures alters its growth from a predominantly hyphal-elongation to a multiple-branching pattern.