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Department of Plant Pathology and Microbiology
The Robert H. Smith Faculty of Agriculture, Food & Environment
The Hebrew University of Jerusalem

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Identification and manipulation of Neurospora crassa genes involved in sensitivity to furfural

Citation:

Feldman, D. ; Kowbel, D. J. ; Cohen, A. ; Glass, N. L. ; Hadar, Y. ; Yarden, O. Identification and manipulation of Neurospora crassa genes involved in sensitivity to furfural. 2019, 12, 210.

Date Published:

2019

Abstract:

Biofuels derived from lignocellulosic biomass are a viable alternative to fossil fuels required for transportation. Following plant biomass pretreatment, the furan derivative furfural is present at concentrations which are inhibitory to yeasts. Detoxification of furfural is thus important for efficient fermentation. Here, we searched for new genetic attributes in the fungus Neurospora crassa that may be linked to furfural tolerance. The fact that furfural is involved in the natural process of sexual spore germination of N. crassa and that this fungus is highly amenable to genetic manipulations makes it a rational candidate for this study.

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